Poisson regression models count outcomes using MLE.
Assume Yi | Xi ~ Poisson(μi) with μi = exp(β0 + β1Xi). Using the exponential link ensures μi > 0.
Interpretation: a one-unit increase in X multiplies the expected count by eβ1. Equivalently, β1 is the change in log μ, an elasticity when X is in logs.
Equidispersion: Poisson requires E[Y] = Var(Y) = μ. If the variance exceeds the mean (overdispersion), Poisson SEs are too small. Use negative binomial regression or quasi-Poisson robust SEs.
Poisson regression is also widely used for difference-in-differences with count outcomes, and is robust to misspecification of the Poisson distribution as long as the conditional mean is correctly specified (Wooldridge 1999).