βj is the effect of Xj on Y, holding all other regressors constant.
This is the ceteris paribus interpretation, all else equal.
Example: in wage = β0 + β1educ + β2exper + ε, the coefficient β1 is the effect of education on wages among workers with the same experience.
This is what makes multiple regression so powerful: it lets us make comparisons we cannot make with simple regression.
But “holding constant” is statistical, not physical. It works only if the model is correctly specified and CLM 4 holds.